Myocardial protection in the acutely injured heart: Hyperpolarizing versus depolarizing hypothermic cardioplegia
نویسندگان
چکیده
منابع مشابه
Custodiol Cardioplegia: A Single-Dose Hyperpolarizing Solution.
Good morning, ladies and gentlemen. Mr. Chairman, it is my great pleasure, but mainly it is an honor for me to be invited for lecturing this audience. I hope I can inform you about some new aspects concerning myocardial protection. The title of my lecture is “Custodiol Cardioplegia: A Single-Dose Hyperpolarizing Solution.” The impact of a low-sodium solution on electrophysiology, physiology, so...
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OBJECTIVES Potassium-based depolarizing St Thomas' Hospital cardioplegic solution No 2 administered as intermittent, oxygenated blood is considered as a gold standard for myocardial protection during cardiac surgery. However, the alternative concept of polarizing arrest may have beneficial protective effects. We hypothesize that polarized arrest with esmolol/adenosine/magnesium (St Thomas' Hosp...
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Objective: Nonhomogeneous distribution of cardioplegia antegradely in severe coronary artery stenosis and evolving acute myocardial infarction has been demonstrated experimentally. Administration of cardioplegia retrogradely causes homogeneous distribution and offers a good alternative for myocardial protection. Methods: Thirty five consecutive patients with three vessel-disease undergoing elec...
متن کاملMyocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits.
PURPOSE To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function. METHODS Rabbits were divided into four groups: Control--C(n=10); ischemic crystalloid cardioplegia--IC(n=10); ischemic blood cardioplegia--IB(n=10); ischemic non cardioplegia--INC(n=10). After the ischemic protocol period t...
متن کاملMyocardial energy metabolism and ultrastructure with polarizing and depolarizing cardioplegia in a porcine model†
OBJECTIVES This study investigated whether the novel St. Thomas' Hospital polarizing cardioplegic solution (STH-POL) with esmolol/adenosine/magnesium offers improved myocardial protection by reducing demands for high-energy phosphates during cardiac arrest compared to the depolarizing St. Thomas' Hospital cardioplegic solution No 2 (STH-2). METHODS Twenty anaesthetised pigs on tepid cardiopu...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1997
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(97)70372-6